Pathophysiology of Temporomandibular Joint Arthritis: Review
주혜민, 김경희, 정성희, 안용우, 옥수민,
소속 상세정보
주혜민 ( Ju Hye-Min ) - Pusan National University Dental Hospital Department of Oral Medicine
김경희 ( Kim Kyung-Hee ) - Inje University Busan Paik Hospital Department of Oral Medicine
정성희 ( Jeong Sung-Hee ) - Pusan National University School of Dentistry Department of Oral Medicine
안용우 ( Ahn Yong-Woo ) - Pusan National University School of Dentistry Department of Oral Medicine
옥수민 ( Ok Soo-Min ) - Pusan National University School of Dentistry Department of Oral Medicine
Abstract
As for temporomandibular joint arthritis (TMJ OA), managing the contributing factors at an early stage through accurate diagnosis is necessary to prevent irreversible bone changes. TMJ OA, which is a multi-organ disease caused by various pathophysiological mechanisms, is developed mainly due to mechanical overload. It is a disease characterized by degeneration of articular cartilage and subchondral bone as a low-level inflammatory arthritis condition developed by dysregulation of catabolic and anabolic activity of chondrocytes. Age, mechanical overload sensing of cartilage, chondrocyte apoptosis, catabolic enzymes, inflammatory factors, abnormal remodeling of subchondral bone, and estrogens may be involved in the pathogenesis of arthritis. Therefore, a comprehensive evaluation is needed to diagnose and manage progressive cartilage degeneration, subchondral bone remodeling, and associated symptoms of TMJ OA.
키워드
Pathophysiology; Temporomandibular joint; Temporomandibular joint arthritis; Temporomandibular joint disorder
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